Cardiovascular effects of an intubating dose of rocuronium 0.6 mg kg-1 in anaesthetized patients, paralysed with vecuronium

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Cardiovascular effects of an intubating dose of rocuronium 0.6 mg kg-1 in anaesthetized patients, paralysed with vecuronium.

We have studied, in adult patients, ASA I-II, the cardiovascular effects of an intubating dose of rocuronium 0.6 mg kg-1. After induction, patients were paralysed with vecuronium and the trachea intubated. Heart rate (HR) and non-invasive mean arterial pressure (MAP) were measured every 1 min. After stabilization of HR and MAP, defined as < 3% change over three measurements, rocuronium (n = 20)...

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Drug Administration Hallucinogen Rating Scale Statistics Results 0.4-mg/kg Dose Perception Somaesthesia Affect Cognition Volition Intensity 0.2-mg/kg Dose 0.1-mg/kg Dose 0.05-mg/kg Dose Hallucinogen Rating Scale Technical Comment on Assessment of Subjective Effects Comment

SUBJECTS, MATERIALS, AND METHODS DRUG ADMINISTRATION HALLUCINOGEN RATING SCALE STATISTICS RESULTS 0.4-MG/KG DOSE PERCEPTION SOMAESTHESIA AFFECT COGNITION VOLITION INTENSITY 0.2-MG/KG DOSE 0.1-MG/KG DOSE 0.05-MG/KG DOSE HALLUCINOGEN RATING SCALE TECHNICAL COMMENT ON ASSESSMENT OF SUBJECTIVE EFFECTS COMMENT REFERENCES

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Neuronal Effects of Sugammadex in combination with Rocuronium or Vecuronium

Rocuronium (ROC) and Vecuronium (VEC) are the most currently used steroidal non-depolarizing neuromuscular blocking (MNB) agents. Sugammadex (SUG) rapidly reverses steroidal NMB agents after anaesthesia. The present study was conducted in order to evaluate neuronal effects of SUG alone and in combination with both ROC and VEC. Using MTT, CASP-3 activity and Western-blot we determined the toxici...

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Safety and tolerability of single intravenous doses of sugammadex administered simultaneously with rocuronium or vecuronium in healthy volunteers.

BACKGROUND Sugammadex rapidly reverses rocuronium- and vecuronium-induced neuromuscular block. To investigate the effect of combination of sugammadex and rocuronium or vecuronium on QT interval, it would be preferable to avoid the interference of anaesthesia. Therefore, this pilot study was performed to investigate the safety, tolerability, and plasma pharmacokinetics of single i.v. doses of su...

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ژورنال

عنوان ژورنال: British Journal of Anaesthesia

سال: 1997

ISSN: 0007-0912

DOI: 10.1093/bja/78.5.586